Understanding the Significance of 109-52-4

Understanding the significance of 109-52-4 is essential as it is the Chemical Abstracts Service (CAS) Registry Number for Spironolactone, a medication widely used for its diuretic and anti-androgen effects. This compound originates from the need to treat conditions such as hypertension and heart failure, showcasing the intersection of chemistry and pharmacology in innovative medical therapies.

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Spironolactone was first introduced to the medical community in the 1950s, with its synthesis stemming from research aimed at developing effective treatments for abnormal fluid retention, or edema. The chemical structure of Spironolactone, designated by the CAS number 109-52-4, reveals its function as an aldosterone antagonist, which helps regulate sodium and potassium levels in the body. This mechanism has made it a cornerstone in managing various cardiovascular diseases, as well as conditions like acne and polycystic ovary syndrome (PCOS).

The argument for the significance of 109-52-4 can be traced through a multi-faceted lens: its therapeutic benefits, the chemical uniqueness of Spironolactone, and its multifarious applications in healthcare. Physicians often prescribe Spironolactone not only for its ability to promote diuresis, helping patients eliminate excess fluid, but also for its capability to block the effects of male hormones, which can treat out-of-balance hormone levels in both men and women. This dual functionality exemplifies the compound's importance and has contributed to its sustained usage across different patient populations.

The significance of 109-52-4 extends beyond individual health treatments to broader public health implications. By effectively managing hypertension and heart failure, Spironolactone reduces the risk of serious cardiovascular events, thereby improving overall population health metrics. Its versatile nature also makes it a subject of research for new applications, encouraging ongoing studies into its potential effects on conditions like heart fibrosis and even certain cancers.

Moreover, the impact of 109-52-4 is reflected in its accessibility and formulation in various pharmaceutical products. Generics have become available, making Spironolactone a cost-effective solution that enhances healthcare accessibility for patients. This availability has propelled further research into optimized usages and combinations with other medications, broadening its role in therapy regimens.

On the molecular level, the unique chemical characteristics associated with the CAS number 109-52-4 facilitate its pivotal role in medical treatments. Understanding its pharmacokinetics—how the drug is absorbed, distributed, metabolized, and excreted—provides insights into optimizing dosages and minimizing side effects, which is crucial for personalized medicine approaches. Increased awareness of Spironolactone’s effects has nurtured an environment where both patients and healthcare providers can make informed choices regarding its use, evidently underscoring its relevance in contemporary medicine.

In conclusion, the examination of 109-52-4 not only affirms its importance as a pharmaceutical agent but also offers a gateway to comprehend the broader implications of drug discovery and application in modern healthcare. As we advance in our understanding of medicinal chemistry, the relevance of compounds like Spironolactone will continue to shape treatment paradigms and ultimately improve patient outcomes.

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